Endocrine Abstracts

Introduction: The aim of the study is to determine whether the guidelines on glycemic control and cardiovascular risk factors are being followed in everyday clinical practice and to describe the lifestyle habits and the wellbeing of patients with Type1 or Type 2 diabetes.Patients and methods: A total of 990 patients with diabetes consecutively followed in the Outpatient Diabetes Clinic were studied (60.8% men). Clinical and laboratory parameters and livi...

Introduction: There is a reduction of the incretin effect in patients with type 2 diabetes secondary to altered secretion of incretin hormones and/or failed of its action.Objective: To study the GLP-1 secretion pattern after an oral glucose tolerance test (OGTT) in postpartum reassessment of women with previous GDM.Materials and methods: Prospective epidemiological study of 48 women with a history of GDM. We evaluated age, history ...

Background: Acromegaly is the consequence of excessive growth hormone (GH) secretion, usually produced by a pituitary adenoma. Transphenoidal surgery is the first-choice treatment; however, the development of new drug therapies in the last years, specially the somatostatin analogues (SSA), has open new and promising avenues for the treatment of pituitary tumors.Objective: To determine whether a detailed knowledge of the clinico-pathological and radiologi...

Vitamin D has a role in the pathogenesis of thyroid autoimmunity.There is evidence in humans that serum levels of 1,25(OH) D3 were found to be significantly lower in patients with autoimmune thyroid diseases.We have evaluated all samples performed in the endocrine labs tested for vitamin D, AbTg, Ab-TPO and TSH from 2006 to 2015; 29216 samples for vitamin D and 41014 for TSH, AbTg and TPO were considered.We s...

Background: Idiopathic intracranial hypertension (IIH) predominantly affects obese women of childbearing age. IIH is characterised by increased intracranial pressure (ICP) which results in visual loss and disabling headaches. ICP dis-regulation results from imbalance of cerebrospinal fluid (CSF) production rate (at the choroid plexus epithelial cells) and drainage. Treatments for IIH are limited but weight loss is established as disease modifying.Glucago...

Craniopharyngiomas are rare solid or mixed solid-cystic tumours. Although benign histologically, these tumours frequently shorten life and should be considered low-grade malignancies.We present the case of a 12-year-old boy diagnosed in 2008, at age 5, with a suprasellar tumour of 22/21/20 mm with mixed solid and cystic areas. The tumour was operated twice by left transfrontal approach in 2008 and right transfrontal approach in 2009. The pathology exam r...

Introduction: The oxidative stress is supposed to be key factor in multiple diseases.The aim of the study was to examine the effects of excessive GH secretion on the blood antioxidant system: total antioxidant capacity (TAC) of plasma; superoxide dismutase (SOD) and catalase activities (CAT); ceruloplasmin (CP); non-protein thiol (NT), and level of thiobarbituric acid reactive substances (TBARS).Materials: Eleven patients with acti...

Introduction: Surgery is the primary therapy in most acromelagic patients. When persistent disease is observed, adjuvant medical therapy is used. Pasireotide is a somatostatin analogue (SSA) not approved for acromegaly therapy yet, but with a potentially better response, given that it binds to four out of five somatostatin receptors.Materials and methods: We present the case of an acromegalic patient with resistance to many therapies and response to trea...

Aim: To estimate the frequency of changes in thyroid function on the background of antiviral therapy in patients with chronic hepatitis C.Material and methods: The retrospective group was consists of 204 patients (mean age 35.5±8.4 years) with HCV genotype 3a, who took the antiviral therapy course with pegylated interferon and ribavirin during 24 weeks. The patients were divided for two groups: 86.3% (176) had a sustained virological response (SVR),...

Introduction: Etomidate is an imidazole derivative which inhibits several enzymatic steps (11β-hydroxylasey, 17β-hydroxylase, 17,20-lyase, cholesterol side-chain cleavage). Intravenous etomidate at sub-anaesthetic doses remains an important option when i.v. administration is required for rapid treatment of severely ill patients with hypercortisolaemia (Cushing’s syndrome, CS) and is almost always very effective.Case series: A 49-year-old w...